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Most nociceptive TRP channels are predominantly expressed in peripheral sensory neurons, but there is also a significant expression in the central nervous system and other tissue and cell types (i.e., keratinocytes, vascular endothelial cells, bladder epithelial cells, fibroblasts and human dental pulp) (Mickle et al., 2+ entry in hippocampal and DRG neurons (Kahya et al., 2015)

Well only know, when we put it to the test

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in iron deficiency anemia this is because total body iron stores are low, and in ACD this is because iron has been sequestered out of the blood